High cell density induces expression from the carbonic anhydrase 9 promoter.
نویسندگان
چکیده
منابع مشابه
Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.
Transcription of the gene coding for the tumor-associated antigen MN/carbonic anhydrase IX (CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1). Previous studies identified CAIX expression in areas adjacent to hypoxic regions in solid tumors and suggested supplementary/alternative modes of regulation. To better understand the mechanisms activating CAIX expression, we characterized the cell...
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Avian sperm are stored in the sperm storage tubules (SSTs) of the hen oviduct for a prolonged period. The impact of avidin-related protein-2 (AVRP2) and carbonic anhydrase II (CA II) in sperm viability in the SSTs has been suggested. The aim of the present study was to investigate the effect of oral administration of a high dose of thyroxine on the oviductal expression of AVRP2<...
متن کاملMAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX.
Transcription of the CA9 gene coding for a tumor-associated carbonic anhydrase IX (CA IX) isoform is regulated by hypoxia via the hypoxia-inducible factor 1 (HIF-1) and by high cell density via the phosphatidylinositol-3-kinase (PI3K) pathway. We examined the role of the mitogen-activated protein kinase (MAPK) pathway in the control of CA9 gene expression. Inhibition of MAPK signaling by U0126 ...
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BACKGROUND Carbonic anhydrase IX has been linked to cancer development and progression. AIM To analyse carbonic anhydrase IX expression and anhydrase inhibition in pancreatic cancer and to correlate these findings with p53 expression and microvessel density. MATERIALS AND METHODS Seventy-seven pancreatic cancers were examined (43 males, 34 females; mean age, 64 years). The anti-carbonic anh...
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In this paper, we used quantum chemical approach to shed light on the catalytic mechanism of γ-carbonic anhydrase (γ-CA) to convert carbon dioxide to bicarbonate ion. Density functional theory (DFT) using B3LYP and UB3LYP functional and three split-valance including 6-31G*, 6-311G** and 6-311++G** basis sets were used to calculate the details of electronic structure and electronic energy of act...
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عنوان ژورنال:
- BioTechniques
دوره 36 2 شماره
صفحات -
تاریخ انتشار 2004